Elegant Defense, An: The Extraordinary New Science of the Immune System: A Tale in Four Lives

(Paperback)

Publishing Details

Classifications

Physical Properties

Description

National Bestseller

"Gives you all the context you need to understand the science of immunity. ... An Elegant Defenseleft me with [a] sense of awe. Bill Gates, Gates Notes Summer Reading List

The Pulitzer PrizewinningNew York Timesjournalist "explicates for the lay reader the intricate biology of our immune system" (Jerome Groopman, MD,New York Review of Books)

From New York Times science journalist Matt Richtel, An Elegant Defense is an acclaimed and definitive exploration of the immune system and the secrets of health. Interweaving cutting-edge science with the intimate stories of four individual patients, this epic, first-of-its-kind book give[s] lay readers a means of understanding whats known so far about the intricate biology of our immune systems (The Week).

The immune system is our bodys essential defense network, a guardian vigilantly fighting illness, healing wounds, maintaining order and balance, and keeping us alive. It has been honed by evolution over millennia to face an almost infinite array of threats. For all its astonishing complexity, however, the immune system can be easily compromised by fatigue, stress, toxins, advanced age, and poor nutritionhallmarks of modern lifeand even by excessive hygiene. Paradoxically, it is a fragile wonder weapon that can turn on our own bodies with startling results, leading today to epidemic levels of autoimmune disorders.

An Elegant Defense effortlessly guides readers on a scientific detective tale winding from the Black Plague to twentieth-century breakthroughs in vaccination and antibiotics, to todays laboratories that are revolutionizing immunologyperhaps the most extraordinary and consequential medical story of our time. Drawing on extensive new interviews with dozens of world-renowned scientists, Richtel has produced a landmark book, equally an investigation into the deepest riddles of survival and a profoundly human tale that is movingly brought to life through the eyes of his four main characters, each of whom illuminates an essential facet of our elegant defense.

Reviews

Vividly told. ... Explicates for the lay reader the intricate biology of our immune system. ...Richtel succeeds in this formidable task. JEROME GROOPMAN, New York Review of Books Deeply affecting. A compelling modern history ofas well as an elegant defense forthe preeminent science of our time. Los Angeles Review of Books Richtel brilliantly blurs the lines between biology primer, medical historical text and the traditional first-person patient story. ... Richtel harnesses his reporters eye for the human condition. Washington Post In this thorough investigation,Richtel details the explosion of knowledge over the past 70 years. ...He weaves into his narrative four case studies[that] add a moving personal dimension. BBC, 10 Books to Read This Month One of those rare nonfiction books that transcends the genre. ... A fascinating and engrossing account of the latest, and quite astonishing, discoveries involving the human immune system. ... An inspiring and wonderful read. ... I highly recommend this extraordinary book. Douglas Preston, #1 bestselling author of The Lost City of the Monkey God A thorough, richly entertaining and just-wonky-enough beginners class in immunology through the case studies of four patients. Wall Street Journal Remarkable. Richtel is a gifted storyteller. A story about cutting-edge science, humanely told. Matt McCarthy, USA Today Matt Richtels AnElegant Defense is a comprehensive and engaging primer on the bodysever-vigilant, omnipresent peacekeeping force. The immune system plays an essentialrole in fighting infections and cancer and inregulating ournormalhealth.Read this superb book to better understand oneof the enduring mysteries of human biology. SANDEEP JAUHAR, New York Times bestselling author of Heart: A History An expert examination of the immune system. Richtel illuminates a complex subject so well that even physicians will learn. Kirkus, STARRED review Richtel approaches this essential subject with awe, his writing meticulous and empathic. Booklist, STARRED Review Award-winning reporter Matt Richtel examines the scientific and human realities of immune anomaly through four case studies. Through these harrowing accounts, Richtel interweaves the research history. Nature, Best Science Picks A deeply reported and entertainingly written exploration of the human immune system and how it works. USA Today (5 Books Not to Miss) Plumbs the enormous impact of the human immune system. Despite the topics staggering complexity the heart and craft of a fine storyteller emerges most memorably. Mercury News A remarkable journey of exploration inside the human body. Richly informative and engaging. Eminently readable and with so many important takeaways,An Elegant Defenseis well worth ones investment of time. Shelf Awareness An engaging deep dive into our immune system. Mens Health Richtels new book is so useful. ... Give[s] lay readers a means of understanding whats known so far about the intricate biology of our immune systems. The Week, Book of the Week Compelling. Richtel enthusiastically and compassionately demystifies the science and the story of one of the most intricate and misunderstood landscapes of human biology. A celebration of life and the journey we all share. Washington Independent Review of Books Enlightening. Readers who suffer from challenged immune systems will welcome validation for the physical and emotional trials they endure, gain deeper understanding of their ailments, and find hope for the future. Readers who are interested in the human bodys capacity to both harm or heal itself will be fascinated. New York Journal of Books A deeply reported account of how the immune system works. Richtel weaves dense, complex research into suspense and human drama; his book reads, at times, like a harrowing mystery novel. Spirituality and Health magazine A hard-to-put-down account of the bodys first line of defense. Publishers Weekly A sweeping overview of immunologys history. ... The prose inAn Elegant Defense is vibrant, conversational, direct and often funny. The content is captivating and useful. Science News [An] entertaining and a worthwhile read. The Missourian Fascinating. ... Rooted in evidence-based research. ... Compelling. AudioFile "Books likeAn Elegant Defensegive mainstream readers insights into that process, insights that run deeper than those a textbook might provide. When we understand how science really works, perhaps we will be a bit less susceptible to anti-scientific seductions. Richtels elegant analogies and compelling human stories will help us remember the basic concepts of modern immunology long after the jargon and acronyms have been forgotten." Commentary Amind-blowing page-turner with moving yet playful human dramas. MindBodyGreen "Fascinating read, especially in the context of a pandemic. Through four personal stories, you discover the captivating complexity of our immune system, written in such a way that its an easy read for the layman." Bloomberg News, A Best Book of 2020 A valuable read that will help you understand what it takes to stop COVID-19. A super interesting look at the science of immunity. Bill Gates

Author Bio

Matt Richtel has been a reporter at the New York Times since 2000. He won the 2010 Pulitzer Prize for National Reporting for a series that exposed the pervasive risks of distracted driving and its root causes, prompting widespread reform. He is the author of A Deadly Wandering, which the New York Times Book Review declared, "deserves a spot next to Fast Food Nation and To Kill a Mockingbird in America's high school curriculum"; it was named a "best book of the year" by the San Francisco Chronicle, Christian Science Monitor, Kirkus Reviews, and Winnipeg Free Press. He has appeared on NPR's Fresh Air, PBS Newshour, and other major media outlets. He lives in San Francisco, California.