Biography of Resistance: The Epic Battle Between People and Pathogens

(Hardback)

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Award-winning Boston University educator and researcher Muhammad H. Zaman provides a chilling look at the rise of antibiotic-resistant superbugs, explaining how we got here and what we must do to address this growing global health crisis.

In September 2016, a woman in Nevada became the first known case in the U.S. of a person who died of an infection resistant to every antibiotic available. Her death is the worst nightmare of infectious disease doctors and public health professionals. While bacteria live within us and are essential for our health, some strains can kill us. As bacteria continue to mutate, becoming increasingly resistant to known antibiotics, we are likely to face a public health crisis of unimaginable proportions. It will be like the great plague of the middle ages, the influenza pandemic of 1918, the AIDS crisis of the 1990s, and the Ebola epidemic of 2014 all combined into a single threat, Muhammad H. Zaman warns.

The Biography of Resistance is Zamans riveting and timely look at why and how microbes are becoming superbugs. It is a story of science and evolution that looks to history, culture, attitudes and our own individual choices and collective human behavior. Following the trail of resistant bacteria from previously uncontacted tribes in the Amazon to the isolated islands in the Arctic, from the urban slums of Karachi to the wilderness of the Australian outback, Zaman examines the myriad factors contributing to this unfolding health crisisincluding war, greed, natural disasters, and germophobiato the culprits driving it: pharmaceutical companies, farmers, industrialists, doctors, governments, and ordinary people, all whose choices are pushing us closer to catastrophe.

Joining the ranks of acclaimed works like Microbe Hunters, The Emperor of All Maladies, and Spillover, A Biography of Resistance is a riveting and chilling tale from a natural storyteller on the front lines, and a clarion call to address the biggest public health threat of our time.

Reviews

A useful, engaging opus New York Times Book Review Antibiotic resistance is a global problema disease present in Karachi one day may arrive in Reno, Nev., the nextyet the same connectivity that has spread resistance has eased collaboration across borders. Mr. Zamans optimism...is welcome, though not always easy to share. Still, his sense of urgency is irresistible. Wall Street Journal "A vivid portrayal of our fight against an opponent that has been around for more than 3 billion years. Zaman, a professor of biomedical engineering and international health, portrays a conflictbetween humans and harmful strains of bacteriathat has played out in plagues and epidemics over millennia." Kirkus Reviews(starred review) I was born under the antibiotic umbrella and took effectiveantibiotics for granted. Yet we still battle pneumonia, which stillkills 800,000 children per year, due to a lack of access. Meanwhile,there is excess use of antibiotics, in humans and animals, causingthe problem of drug-resistant infections. This book tells you the storyof the people who set up the antibiotic umbrella and the challengeto keep it upfor all of us, together, as one humanity. Becauseno wall will ever protect us against drug-resistant infections. Stefan Swartling Peterson, chief of health, UNICEF If you read one book this year, please make it this one.A breathtaking, inspiring, and very personal account of one of thegreatest challenges of our timedrug-resistant infectionsan issue thatwill undermine the whole of modern medicine unless we act, and we actnow. This book is about what has made modern medicine possibletheability to control and treat infections. This book fills one with hope thatscience can overcome the challenge, politicians can act, policies can work,and drug-resistant infections do not need to be the end of modernmedicine. It is enthralling, engaging, and beautifully written. Sir Jeremy Farrar, director of Wellcome Trust Biography of Resistance is a sweeping and engaging history of thetango humanity dances with bacteriawhich both make human lifepossible and have the capacity to end it. Our efforts in the past hundredyears to gain the upper hand have led to remarkable successesbut nowmay be backfiring as antimicrobial resistance looms as the biggest publichealth challenge of our time. Dr. Zamans story is timely and urgent. Kathleen Sebelius, former United States Secretaryof Health and Human Services

Author Bio

Muhammad H. Zaman is Howard Hughes Medical Institute Professor of Biomedical Engineering and International Health at Boston University. Prof. Zaman's current research is focused on three areas namely using quantitative tools to understand tumor metastasis, developing robust technologies for high-value healthcare problems in the developing world, particularly in the area of maternal and child health and working on health and innovation policy issues in developing nations. Technologies developed by Prof. Zaman are in various stages of implementation in several countries. In 2013, Scientific American named a technology from Zaman lab, PharmaChk, among the 10 technologies that will change the world. He has won numerous awards for his research and teaching from IEEE, FEBS, American Society for Engineering Education, USAID, The US National Academy of Sciences, The University of Texas System, Boston University and other national and international organisations. Most recently, he was named Howard Hughes Professor by the Howard Hughes Medical Institute and was elected as a Fellow of American Institute of Biological and Medical Engineering. In addition to his research, Prof. Zaman is actively engaged in bringing quality engineering education in several developing nations. He is currently involved in setting up biomedical engineering departments at universities in Kenya, Zambia, Uganda and Ethiopia. He is co-Director of the UN Africa Biomedical Initiative. He is a regular contributor on issues of drug quality control and global health for the Project Syndicate (his columns have appeared in newspapers in more than 20 countries), Huffington Post and writes a weekly column on innovation in health and education for leading Pakistan daily, Express Tribune which is part of the International New York Times group.